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Showing 1–4 of 4 results
Advanced filters: Author: "Nissim Benvenisty" Clear advanced filters

  • The use of cultured human pluripotent stem cells (PSCs) to model human diseases has revolutionized the ways in which we study monogenic, multigenic and epigenetic disorders, by overcoming some of the limitations of animal models. PSC-based disease models are generated using various strategies and can be used for the discovery of new drugs and therapies.

    • Yishai Avior
    • Ido Sagi
    • Nissim Benvenisty
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 170-182

  • Human stem cells that can give rise to every cell type in the body are major players in biomedical research. A molecular analysis of human embryos might help to make these cultured cells more authentic imitations of their in vivo counterparts.

    • Ido Sagi
    • Nissim Benvenisty
    News & Views
    Nature
    Volume: 540, P: 211-212

  • New guidelines from the International Society for Stem Cell Research offer a model for self-regulation in contentious areas, write Jonathan Kimmelman and colleagues.

    • Jonathan Kimmelman
    • Insoo Hyun
    • George Q. Daley
    Comments & Opinion
    Nature
    Volume: 533, P: 311-313

  • The unique ability of human pluripotent stem cells to self-renew and to differentiate into cells of the three germ layers makes them an invaluable tool for the future of regenerative medicine and tumorigenic research. It was assumed that human induced pluripotent stem cells (HiPSCs) would behave like their embryonic counterparts in respect to their tumorigenicity, but a rapidly accumulating body of evidence suggests that there are important differences.

    • Uri Ben-David
    • Nissim Benvenisty
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 268-277