Undifferentiated 'cancer stem cells' (CSCs) are at the base of the tumour hierarchy, driving tumour growth and propagation. In this Perspectives article, the authors argue precise preclinical studies are needed to delineate prostate tumour cell hierarchy. Only then will the development of efficient differentiation agents—drugs that drive CSCs to differentiated cells that are susceptible to therapy—be possible.
- Jayant K. Rane
- Davide Pellacani
- Norman J. Maitland
