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Showing 1–5 of 5 results
Advanced filters: Author: "O Smith" Clear advanced filters

  • Rhodopsin signalling is triggered by the light-induced isomerization of its 11-cisretinal chromophore. Here, the authors use NMR spectroscopy to define retinal orientation and interactions in the active metarhodopsin II intermediate, proposing a two-stage mechanism for rhodopsin activation.

    • Naoki Kimata
    • Andreyah Pope
    • Steven O. Smith
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Solid-state NMR analyses reveal that the free backbone carbonyl groups associated with proline residues in the transmembrane helices play a key role in mediating rhodopsin activation.

    • Naoki Kimata
    • Andreyah Pope
    • Steven O Smith
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 738-743

  • Endonuclease V can initiate the repair of deaminated purine bases by recognizing them and hydrolyzing the second phosphodiester bond on their 3′ side. Now the crystal structures of endonuclease V in complex with its substrate and its product reveal a wedge motif acting as a minor groove–damage sensor and a pocket to recognize the lesion; the enzyme remains tightly bound to the 5′ phosphate product, perhaps to hand it over to downstream repair factors.

    • Shivani Ahuja
    • Viktor Hornak
    • Markus Eilers
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 168-175

  • Amyloid-β42 (Aβ42) peptide aggregates to form oligomers, protofibrils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. Structural and functional analyses show that the conversion of Aβ42 oligomers to fibrils is accompanied by reduced neurotoxicity and involves the formation of parallel, in-register β-sheets that are staggered at an intermolecular contact.

    • Mahiuddin Ahmed
    • Judianne Davis
    • Steven O Smith
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 561-567