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Showing 1–5 of 5 results
Advanced filters: Author: "Oliver Bell" Clear advanced filters

  • In this Viewpoint article, experts provide their current opinions on heterochromatin definition, types and functional mechanisms.

    • Oliver Bell
    • Adam Burton
    • Maria-Elena Torres-Padilla
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 691-694

  • Through a genetic screen, the authors find that the cohesin regulator PDS5A is required for Polycomb target gene silencing. Derepression upon cohesin dysregulation is linked to loss of Polycomb loops without change in repressive chromatin domains.

    • Daniel Bsteh
    • Hagar F. Moussa
    • Oliver Bell
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to promote gene silencing. Here the authors use reversible tethering of Polycomb proteins to ectopic sites in mouse ESCs and find that canonical but not variant PRC1 can trigger sequence-independent propagation of Polycomb-mediated transcriptional repression.

    • Hagar F. Moussa
    • Daniel Bsteh
    • Oliver Bell
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Genome-scale methods are providing increasingly detailed views of nucleosome organization and chromatin structure. This is enhancing our understanding of how DNA-based reactions occur in the context of chromatin and how they are influenced by genome accessibility.

    • Oliver Bell
    • Vijay K. Tiwari
    • Dirk Schübeler
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 554-564