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Showing 1–15 of 15 results
Advanced filters: Author: "Olivier Schwartz" Clear advanced filters

  • SARS-CoV-2 evolved into several sublineages harboring different mutations in spike. Here, the authors isolate and characterize nine SARS-CoV-2 variants and show that EG.5.1.3 has highest fitness in nasal epithelial cells, while JN.1 shows lower affinity to ACE2 and higher immune evasion compared to BA.2.86.1.

    • Delphine Planas
    • Isabelle Staropoli
    • Olivier Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • We demonstrate that the transmembrane protease TMPRSS2 is a receptor for coronavirus HKU1; it triggers HKU1-mediated cell–cell fusion and viral entry by binding to both HKU1A and HKU1B spikes.

    • Nell Saunders
    • Ignacio Fernandez
    • Olivier Schwartz
    Research
    Nature
    Volume: 624, P: 207-214

  • In this work, Planas et al. report that Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 escape neutralization from monoclonal antibodies, and sera from vaccinated individuals with or without Omicron BA.1/2 or BA.5 breakthrough infection.

    • Delphine Planas
    • Timothée Bruel
    • Olivier Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Therapeutic antibodies, and sera from immunocompromised individuals prophylactically treated with therapeutic antibodies, differ in neutralizing activity against the SARS-CoV-2 Omicron BA.1 and BA.2 sublineages, which could have implications for pre-exposure and post-exposure treatment.

    • Timothée Bruel
    • Jérôme Hadjadj
    • Olivier Schwartz
    Research
    Nature Medicine
    Volume: 28, P: 1297-1302

  • The SARS-CoV-2 Delta variant partially evades neutralization by several monoclonal antibodies and by sera from individuals who have had COVID-19, but two doses of anti-COVID-19 vaccines still generate a strong neutralizing response.

    • Delphine Planas
    • David Veyer
    • Olivier Schwartz
    Research
    Nature
    Volume: 596, P: 276-280

  • Sera from convalescent individuals with coronavirus disease 2019 and from individuals vaccinated with BNT162b2 have reduced ability to neutralize SARS-CoV-2 variants B1.1.7 and B.1.351, but antibody potency against the variants increases after two vaccine doses.

    • Delphine Planas
    • Timothée Bruel
    • Olivier Schwartz
    Research
    Nature Medicine
    Volume: 27, P: 917-924

  • The success and pathogenicity of HIV-1 largely resides in the function of the viral protein Nef. Here, the authors propose that Nef modulates a T cell's ability to form an immunological synapse and modulates T-cell activation to favour viral replication and spread.

    • Oliver T. Fackler
    • Andres Alcover
    • Olivier Schwartz
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 310-317

  • SAMHD1 has emerged as a novel HIV restriction factor that inhibits viral replication by limiting dNTP availability. Here, Schwartz and colleagues discuss the studies that led to the identification and characterization of SAMHD1, and speculate on why HIV-1 does not encode the SAMHD1-targeting protein, Vpx.

    • Diana Ayinde
    • Nicoletta Casartelli
    • Olivier Schwartz
    Reviews
    Nature Reviews Microbiology
    Volume: 10, P: 675-680

  • The magnitude of immune evasion of Omicron raises the question whether it should be considered as a distinct SARS-CoV-2 serotype. Here, we discuss lines of evidence in support or against the concept of SARS-CoV-2 serotypes, and the implications of this classification.

    • Etienne Simon-Loriere
    • Olivier Schwartz
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 20, P: 187-188

  • Macrophages infected with human immunodeficiency virus type 1 emit long intercellular conduits that shuttle the viral protein Nef to bystander B cells, where it impairs cellular function and immunoglobulin class switching.

    • Dominika Rudnicka
    • Olivier Schwartz
    News & Views
    Nature Immunology
    Volume: 10, P: 933-934

  • Langerhans cells in the skin and mucosa have been thought to mediate the spread of HIV-1 in the body during sexual transmission. Instead, it seems that the cells protect against the virus, a finding with implications for the development of microbicides (pages 367–371).

    • Olivier Schwartz
    News & Views
    Nature Medicine
    Volume: 13, P: 245-246

  • Chikungunya virus is a re-emerging alphavirus that recently caused an epidemic in countries of the Indian Ocean. At the time, little was known about the biology and pathogenesis of this virus compared with other viruses, but recent multidisciplinary efforts have furthered our understanding of this pathogen and its interaction with the host.

    • Olivier Schwartz
    • Matthew L. Albert
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 491-500