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Showing 1–11 of 11 results
Advanced filters: Author: "Olle Lindvall" Clear advanced filters
  • A differentiation protocol guided by developmental principles produces more-authentic dopaminergic neurons for transplantation in patients.

    • Olle Lindvall
    News & Views
    Nature Biotechnology
    Volume: 30, P: 56-58
  • Parkinson's disease is characterized by progressive neurodegeneration, but the underlying mechanisms are unclear. Brundin and colleagues discuss how recent reports on the outcome of neuronal grafts carried out in patients with Parkinson's disease might shed light on the disease's progression.

    • Patrik Brundin
    • Jia-Yi Li
    • Tamas Revesz
    Reviews
    Nature Reviews Neuroscience
    Volume: 9, P: 741-745
  • Unlike tissues such as skin and liver, the adult brain has long been thought to have little capacity for self-repair. But new results indicate that, after cells in the cortex are damaged, undifferentiated cells from other regions of the brain may be recruited to replace them.

    • Anders Björklund
    • Olle Lindvall
    News & Views
    Nature
    Volume: 405, P: 893-895
  • Current therapies for Parkinson disease focus mainly on symptomatic relief, but gene therapy approaches may offer the prospect of halting or reversing the progress of the disease process itself. A recent study provides evidence that sustained delivery of glial cell line-derived neurotrophic factor to the nigrostriatal system provides neuroprotection and functional recovery in a primate model of Parkinson disease.

    • Anders Björklund
    • Olle Lindvall
    News & Views
    Nature Medicine
    Volume: 6, P: 1207-1208
  • Immune cells participating in CNS inflammation are now known to mediate both beneficial and detrimental effects. In this review, the authors examine the recently discovered bidirectional relationship between immune cells and neural stem cells and how these interactions may influence brain repair and provide new therapeutic targets.

    • Zaal Kokaia
    • Gianvito Martino
    • Olle Lindvall
    Reviews
    Nature Neuroscience
    Volume: 15, P: 1078-1087