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Showing 1–3 of 3 results
Advanced filters: Author: "Olov Andersson" Clear advanced filters

  • Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta-cell regeneration.

    • Christos Karampelias
    • Habib Rezanejad
    • Olov Andersson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • MNK2 was identified as the target of a small molecule named CID661578 that can stimulate pancreatic β-cell generation in zebrafish, pig and human organoids. CID661578 prevents MNK2 from binding to eIF4G in the translation initiation complex.

    • Christos Karampelias
    • Kathleen Watt
    • Olov Andersson
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 18, P: 942-953