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Showing 1–2 of 2 results
Advanced filters: Author: "Panagiotis A. Konstantinopoulos" Clear advanced filters

  • In epithelial ovarian cancer, gene-expression profiling has been used to provide prognostic information, to predict response to first-line platinum-based chemotherapy, and to discriminate between different histologic subtypes. The authors of this Review summarize the contributions of gene-expression profiling to the diagnosis and management of epithelial ovarian cancer and discuss ways in which this technique could become a useful tool in clinical management.

    • Panagiotis A Konstantinopoulos
    • Dimitrios Spentzos
    • Stephen A Cannistra
    Reviews
    Nature Clinical Practice Oncology
    Volume: 5, P: 577-587

  • Members of the RAS superfamily of monomeric GTPases are promising anticancer targets, but previous attempts to therapeutically modulate their activity, which have focused on the development of farnesyltransferase inhibitors, have not proved as successful as hoped. The authors discuss novel approaches targeting prenylation and post-prenylation modifications and the functional regulation of GDP/GTP exchange as exciting alternatives for anticancer therapy.

    • Panagiotis A. Konstantinopoulos
    • Michalis V. Karamouzis
    • Athanasios G. Papavassiliou
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 541-555