Although the roles of individual phospholipases and their lipid mediators in cancer have been studied extensively, it is less clear how these enzymes interact with each other and other cellular pathways to affect cancer-associated processes. This Opinion article argues that a thorough understanding of phospholipase signalling networks is necessary to determine whether these enzymes can be targeted therapeutically.
- Jong Bae Park
- Chang Sup Lee
- Sung Ho Ryu
