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Showing 1–10 of 10 results
Advanced filters: Author: "Paola Romagnani" Clear advanced filters

  • Lineage tracing is a sophisticated technique to track cellsin vivo. Here, Paola Romagnani and colleagues describe how lineage tracing can be used to track the fate of cells involved in renal development, pathophysiological changes and regeneration. The authors discuss considerations in selecting an appropriate reporter, promoter, and activating switch for lineage tracing experiments, and approaches to data interpretation.

    • Paola Romagnani
    • Yuval Rinkevich
    • Benjamin Dekel
    Reviews
    Nature Reviews Nephrology
    Volume: 11, P: 420-431

  • Acute kidney injury is frequent, often fatal and can leave survivors with chronic kidney disease. Here the authors show that tubular cell polyploidy reduces early fatality sustaining residual function but promotes chronic kidney disease, which can be prevented by blocking YAP1

    • Letizia De Chiara
    • Carolina Conte
    • Paola Romagnani
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Two types of parietal podocyte were previously described in the Bowman capsule: one characterized by coexpression of podocyte and parietal epithelial cell markers, the other characterized by expression of podocyte markers only. New research demonstrates that these populations represent podocyte progenitors and ectopic podocytes—distinct cell types with different clinical implications.

    • Laura Lasagni
    • Paola Romagnani
    News & Views
    Nature Reviews Nephrology
    Volume: 9, P: 715-716

  • A new study demonstrates that knockdown of miR-193a in human parietal epithelial cells induces their differentiation into podocytes. Inhibition of miR-193a in a model of nephrotoxic nephritis resulted in reduced proteinuria and crescent formation. These data suggest that promoting differentiation of parietal progenitors into podocytes has potential therapeutic relevance.

    • Elena Lazzeri
    • Paola Romagnani
    News & Views
    Nature Reviews Nephrology
    Volume: 11, P: 7-8

  • The cellular origins of angiomyolipoma and other tuberous sclerosis complex-associated neoplasms are unknown. Now, two studies show that these neoplasms derive from cancer stem cells that originate from multipotent renal epithelial cells. The new findings provide a link between stemness and tumorigenesis in the kidney.

    • Francesca Becherucci
    • Paola Romagnani
    News & Views
    Nature Reviews Nephrology
    Volume: 14, P: 215-216

  • The recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplication.

    • Elena Lazzeri
    • Maria Lucia Angelotti
    • Paola Romagnani
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • Cysts were generated from organoids in vitro and the removal of adherent cues was shown to play a key role in polycystic kidney disease progression. These cysts resembled those of diseased tissue phenotypically and were capable of remodelling their microenvironment.

    • Paola Romagnani
    News & Views
    Nature Materials
    Volume: 16, P: 1058-1059

  • Podocytopathies are kidney diseases in which podocyte injury drives proteinuria or nephrotic syndrome. This Primer discusses a shift in paradigm from patient stratification based on kidney biopsy findings towards personalized management based on clinical, morphological and genetic data.

    • Jeffrey B. Kopp
    • Hans-Joachim Anders
    • Paola Romagnani
    Reviews
    Nature Reviews Disease Primers
    Volume: 6, P: 1-24

  • Cellular regeneration—the repair of portions of the existing nephron after tubular damage—is conserved in all animal species. By contrast, nephron neogenesis is present in lower branches of the animal kingdom, but not in adult mammals. Converging evidence suggests that a renal progenitor system is present in the adult kidney across different stages of evolution. Here, the authors look at renal regeneration from an evolutionary perspective and suggest possible explanations for the differences between animals.

    • Paola Romagnani
    • Laura Lasagni
    • Giuseppe Remuzzi
    Reviews
    Nature Reviews Nephrology
    Volume: 9, P: 137-146