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Showing 1–3 of 3 results
Advanced filters: Author: "Pascal Meier" Clear advanced filters

  • In this Review, Meier et al. discuss the molecular mechanisms of necroptosis, delineate how this form of immunogenic cell death activates antitumour immune responses and explore the opportunities and limitations of targeting necroptosis for anticancer therapy.

    • Pascal Meier
    • Arnaud J. Legrand
    • John Silke
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 299-315

  • The inhibitor of apoptosis (IAP) proteins were first investigated because of their capacity to inhibit programmed cell death in response to a number of physiological stimuli. Their disruption is also evident in many types of human cancer. As small pharmacological inhibitors of IAPs enter clinical trials, this Review examines what we now know about the function of a subset of family members — cIAP1, cIAP2 and XIAP.

    • Mads Gyrd-Hansen
    • Pascal Meier
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 561-574

  • Toll-like receptors have important functions in immunity and development across the animal kingdom. An evolutionary analysis suggests that the analogous immune functions have arisen independently in vertebrates and invertebrates.

    • François Leulier
    • Bruno Lemaitre
    Reviews
    Nature Reviews Genetics
    Volume: 9, P: 165-178