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Showing 1–12 of 12 results
Advanced filters: Author: "Pascale Cossart" Clear advanced filters

  • In this Progress article, Cossart and colleagues discuss the unique features of unusually long antisense RNAs and discuss the excludon paradigm, which describes a genomic locus that encodes a long antisense RNA which inhibits the expression of one operon while simultaneously driving the expression of the adjacent operon.

    • Nina Sesto
    • Omri Wurtzel
    • Pascale Cossart
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 75-82

  • Septins are highly conserved, GTP-binding proteins that form hetero-oligomeric complexes and higher-order structures, such as filaments and rings. By acting as scaffolds or diffusion barriers, they have roles in numerous biological processes, including cell division and host–pathogen interactions.

    • Serge Mostowy
    • Pascale Cossart
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 183-194

  • SUMOylation is a post-translational protein modification that affects many eukaryotic cellular processes. It is shown here that cellular infection with Listeria monocytogenes induces degradation of one of the essential SUMOylation enzymes, Ubc9, through a mechanism that involves a bacterial toxin, listeriolysin O. This effect on SUMOylation may support efficient infection by Listeria.

    • David Ribet
    • Mélanie Hamon
    • Pascale Cossart
    Research
    Nature
    Volume: 464, P: 1192-1195

  • The bacterial stressosome is a large nanomachine and a key inducer of stress response. Here, the authors present the cryo-EM structure of the stressosome from the bacterial pathogen Listeria monocytogenes at 3.38 Å resolution and discuss its activation mechanism.

    • Allison H. Williams
    • Adam Redzej
    • Pascale Cossart
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • ISG15 is a ubiquitin-like modifier that can be upregulated in response to bacterial infections. Here, the authors use proteomics to identify endogenous ISGylation substrates in the liver of Listeria monocytogenes infected mice and show that ISGylation alters basal and infection-induced autophagy.

    • Yifeng Zhang
    • Fabien Thery
    • Lilliana Radoshevich
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Until recently, large-scale transcriptome studies in bacteria and archaea were limited by technical challenges, and there was a perception that microbial transcription was relatively simple compared with eukaryotic transcription. Now, prokaryotic transcriptomics is revealing unexpected aspects of transcriptional control, genome organization and non-coding RNAs.

    • Rotem Sorek
    • Pascale Cossart
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 9-16

  • Listeria monocytogenes is responsible for severe food-borne infections. The first global comparative transcriptome analysis of this species reveals successive and coordinated global transcriptional changes during infection and points to previously unknown regulatory mechanisms in bacteria.

    • Alejandro Toledo-Arana
    • Olivier Dussurget
    • Pascale Cossart
    Research
    Nature
    Volume: 459, P: 950-956

  • The elaborate and skilful host-cell manipulations ofListeria monocytogenes provide researchers with a powerful model system to study host–pathogen interactions, as well as bacterial pathophysiology and adaptation. In addition, L. monocytogenescan be used as a tool to explore fundamental cellular processes such as cytoskeletal dynamics and cellular adhesion.

    • Mélanie Hamon
    • Hélène Bierne
    • Pascale Cossart
    Reviews
    Nature Reviews Microbiology
    Volume: 4, P: 423-434

  • Pathogenic bacteria need to respond rapidly to changes in their environment to adjust their gene expression and physiology. Johansson and colleagues review the role of RNAs, including 5′ untranslated regions (UTRs), 3′ UTRs,cis-acting antisense RNAs and trans-acting small non-coding RNAs, as regulatory molecules of bacterial virulence.

    • Jonas Gripenland
    • Sakura Netterling
    • Jörgen Johansson
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 857-866