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Showing 1–5 of 5 results
Advanced filters: Author: "Patrick Tan" Clear advanced filters

  • Clinically significant genetic variation in Asian populations is under-characterized. Here, the authors show the diversity in prevalence and spectrum of human disease and pharmacogenetic variants in a multi-ethnic Asian population.

    • Sock Hoai Chan
    • Yasmin Bylstra
    • Weng Khong Lim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • This Perspective article discusses Singapore’s efforts to implement a National Precision Medicine Strategy through the integration of genomic, clinical and lifestyle data of up to one million Singaporean individuals.

    • Eleanor Wong
    • Nicolas Bertin
    • Patrick Tan
    Reviews
    Nature Genetics
    Volume: 55, P: 178-186

  • ColoPrint® is an 18-gene expression signature designed to predict disease relapse in patients with early-stage colorectal cancer (CRC). We discuss the potential impact of ColoPrint® on clinical practice, and its contribution to our knowledge of CRC molecular heterogeneity.

    • Iain B. Tan
    • Patrick Tan
    News & Views
    Nature Reviews Clinical Oncology
    Volume: 8, P: 131-133

  • Gastric cancer is a deadly malignancy and accumulating evidence suggests that epigenetic abnormalities promote carcinogenesis. Here, the authors summarize the gastric cancer epigenome, highlighting key advances from studies of DNA methylation and histone modifications, and how these findings might lead to therapeutic opportunities.

    • Nisha Padmanabhan
    • Toshikazu Ushijima
    • Patrick Tan
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 14, P: 467-478

  • Gastrointestinal malignancies are among the most common human cancers. Genomic and transcriptomic analyses have identified recurring molecular subtypes that suggest important biological differences. Here, the authors review the common themes of gastrointestinal cancer subtypes, as well as how they could be implemented into clinical practice.

    • Maarten F. Bijlsma
    • Anguraj Sadanandam
    • Louis Vermeulen
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 14, P: 333-342