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Showing 1–2 of 2 results
Advanced filters: Author: "Paul Elliott" Clear advanced filters
  • OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 complex, which reveals a secondary interface through which OTULIN non-catalytically antagonizes SNX27 retromer assembly and cargo loading.

    • Aurelia Stangl
    • Paul R. Elliott
    • Daniel Krappmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18
  • Cardiovascular disease (CVD) remains a leading cause of death worldwide, but age-standardized CVD death rates are decreasing steadily. In this Review, Ezzati and colleagues use the available epidemiological data to examine regional and global changes in CVD mortality, as well as trends in smoking, alcohol consumption, diet, physiological risk factors, and improvements in medical care that might underlie these changes.

    • Majid Ezzati
    • Ziad Obermeyer
    • David A. Leon
    Reviews
    Nature Reviews Cardiology
    Volume: 12, P: 508-530