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Advanced filters: Author: "Paul Flicek" Clear advanced filters

  • A comparison of regulatory DNA sequences in humans, macaques and mice during embryonic limb development reveals thousands of sites of enhanced regulatory activity that are likely to have driven the evolution of our characteristic anatomy.

    • Paul Flicek
    News & Views
    Nature
    Volume: 500, P: 158-159

  • The rate and mechanisms of evolution of transcription factor binding show striking differences across diverse metazoan phyla. This Review highlights insights gained from sequence-based comparisons of genomes and ChIP–seq studies analysing the evolution of transcription factor binding, as well as their conceptual contribution to models of regulatory evolution and gene expression control.

    • Diego Villar
    • Paul Flicek
    • Duncan T. Odom
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 221-233