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Showing 1–3 of 3 results
Advanced filters: Author: "Paul G. Thomas" Clear advanced filters

  • The binding of foreign peptides to host major histocompatibility complex (MHC) forms the basis of adaptive immune recognition. The MHC and T cell receptors (TCRs) use diverse structural solutions to enhance peptide presentation and recognition, and two new reports provide insights into noncanonical modes of detection and binding.

    • Pradyot Dash
    • Paul G Thomas
    News & Views
    Nature Structural & Molecular Biology
    Volume: 24, P: 339-341

  • A systems biology approach provides correlates of successful vaccination, which allows a new method for measuring early vaccine efficiency and suggests hypotheses for the mechanisms that underlie immunogenicity.

    • Paul G Thomas
    • Peter C Doherty
    News & Views
    Nature Immunology
    Volume: 10, P: 14-16

  • Lipid second messengers such as phosphatidic acid (PtdOH) have a role in a wide range of pathological processes, and phospholipase D (PLD) enzymes are one of the major sources of signal-activated PtdOH generation. In this Review, Brown, Thomas and Lindsley discuss the development of PLD inhibitors, with a focus on isoform-specific inhibitors, and their potential applications in the treatment of cancer, neurodegeneration and infection.

    • H. Alex Brown
    • Paul G. Thomas
    • Craig W. Lindsley
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 351-367