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Showing 1–2 of 2 results
Advanced filters: Author: "Per A. Peterson" Clear advanced filters

  • Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are crucial for the formation and remodelling of blood vessels. VEGFR2, which is the main endothelial VEGFR, is regulated by receptor-interacting proteins, endocytosis and trafficking. Recent insights have been gained into these layers of regulation and the crosstalk between VEGFR2 signalling and other endothelial signalling cascades.

    • Michael Simons
    • Emma Gordon
    • Lena Claesson-Welsh
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 611-625

  • Vascular endothelial growth factors (VEGFs) regulate vascular development during embryogenesis and angiogenesis in the adult. The recently developed cancer treatments that target VEGF receptor activation highlight the clinical relevance of inhibiting VEGF pathways that are exaggerated in pathological angiogenesis.

    • Anna-Karin Olsson
    • Anna Dimberg
    • Lena Claesson-Welsh
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 359-371