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Advanced filters: Author: "Per-Johan Jakobsson" Clear advanced filters
  • Macrophages have important roles in the induction and resolution of inflammation, but the intracellular pathways from inflammatory signals to pain response remain unclear. A recent study demonstrates that the P2X4 receptor mediates inflammatory pain by inducing formation of the potent lipid mediator prostaglandin E2.

    • Per-Johan Jakobsson
    News & Views
    Nature Reviews Rheumatology
    Volume: 6, P: 679-681
  • Eicosanoids are major regulators of inflammation and are thought to be involved in the pathogenesis of rheumatic diseases. Here, the authors provide an overview of eicosanoid pathways in a variety of rheumatic diseases (including rheumatoid arthritis, osteoarthritis and gout, among others) and describe how targeting this pathway might lead to novel anti-inflammatory treatment strategies.

    • Marina Korotkova
    • Per-Johan Jakobsson
    Reviews
    Nature Reviews Rheumatology
    Volume: 10, P: 229-241