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Showing 1–3 of 3 results
Advanced filters: Author: "Peter K. Gregersen" Clear advanced filters

  • Making causative connections between genotypic and phenotypic variation is a major challenge for geneticists engaged in the study of human disease. A study drawing this connection for a type 1 diabetes risk locus now demonstrates the importance of focusing on specific quantitative traits and studying them in normal subjects.

    • Peter K Gregersen
    News & Views
    Nature Genetics
    Volume: 41, P: 958-959

  • A new study reports the mapping of gene expression in primary immune cell subsets, showing the presence of cell type–specific cis and trans expression quantitative trait loci (eQTLs). The identification of cell type–specific trans-regulated networks can inform functional studies of susceptibility loci identified from genome-wide association studies for human complex diseases.

    • Peter K Gregersen
    News & Views
    Nature Genetics
    Volume: 44, P: 478-480

  • Combined with advances in immunology, genetic studies in human populations are revealing the diverse alterations in adaptive immunity that underlie autoimmune diseases. Recent studies have also highlighted an unexpected contribution of the innate immune system to these complex diseases.

    • Peter K. Gregersen
    • Timothy W. Behrens
    Reviews
    Nature Reviews Genetics
    Volume: 7, P: 917-928