Bile acids have a crucial role in the digestion of dietary lipids and as signalling molecules in a number of metabolic pathways. Bile acid receptors have become attractive therapeutic targets for liver disease and metabolic disorders. Here, the authors provide an overview of bile acid signalling in humans and highlight the therapeutic potential of compounds that target these pathways.
- Frank G. Schaap
- Michael Trauner
- Peter L. M. Jansen