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Showing 1–7 of 7 results
Advanced filters: Author: "Peter M. Visscher" Clear advanced filters

  • Identity by descent (IBD) — the probability that two alleles descended from a common ancestor — is used in fundamental applications such as gene mapping and estimating heritability. The authors offer a solution to the confusion between IBD and identity by state (IBS) that is caused by the common practice of using dense SNPs to estimate IBD.

    • Joseph E. Powell
    • Peter M. Visscher
    • Michael E. Goddard
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 800-805

  • The data from genome-wide association studies can be applied to genotype data to predict the phenotype of a complex trait. Here the authors discuss the potential pitfalls of such analyses and the inherent limitations of the method.

    • Naomi R. Wray
    • Jian Yang
    • Peter M. Visscher
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 507-515

  • Epidemiological studies and anecdotal evidence show overlap between psychiatric disorders and creativity, but why? A new study uses genome-wide association data from schizophrenia and bipolar disorder to show that genetics are part of the explanation.

    • Matthew C Keller
    • Peter M Visscher
    News & Views
    Nature Neuroscience
    Volume: 18, P: 928-929

  • A new analysis has identified hundreds of loci that are associated with multiple traits or diseases by comparing genome-wide association study (GWAS) data for 42 complex traits. The study uses the power of GWAS to provide evidence of pairs of traits with a likely causal relationship.

    • Peter M Visscher
    • Jian Yang
    News & Views
    Nature Genetics
    Volume: 48, P: 707-708

  • Identifying causal variants for complex traits and understanding their function remain arduous tasks. A new study combines the advantages of gene mapping in livestock with elegant genetic and functional analyses to address these challenges and identifies candidate regulatory variants affecting stature in cattle.

    • Peter M Visscher
    • Michael E Goddard
    News & Views
    Nature Genetics
    Volume: 43, P: 397-398

  • Genome-wide association studies have identified many variants affecting susceptibility to disease. Now, three studies use this approach to study adult height variation in a combined sample size of ∼63,000 individuals and report a total of 54 validated variants influencing this trait.

    • Peter M Visscher
    News & Views
    Nature Genetics
    Volume: 40, P: 489-490

  • There are various measures to quantify the contribution of genetic variants to disease risk, but differing terminology and assumptions obfuscate their use and interpretation. In this Analysis, the authors consider and contrast six commonly used measures that assess disease risk of individual variants, and provide numerical examples in breast cancer, Crohn's disease, rheumatoid arthritis and schizophrenia.

    • John S. Witte
    • Peter M. Visscher
    • Naomi R. Wray
    Research
    Nature Reviews Genetics
    Volume: 15, P: 765-776