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Showing 1–4 of 4 results
Advanced filters: Author: "Peter Rugg-Gunn" Clear advanced filters

  • The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood. Here the authors generate a high-resolution atlas of gene regulatory interactions, chromatin profiles and transcription factor occupancy in naive and primed human pluripotent stem cells to provide insights into these developmental processes.

    • Peter Chovanec
    • Amanda J. Collier
    • Peter J. Rugg-Gunn
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Here the authors show satellite transcripts in mouse embryonic stem cells drive HP1α into droplets in vitro and also control HP1α organisation and association with chromatin in vivo. Depleting the satellite transcripts converts heterochromatin into a less dynamic and more static state and leads to chromosome instability.

    • Clara Lopes Novo
    • Emily V. Wong
    • Peter J. Rugg-Gunn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Cell identity is shaped by a complex interplay between transcription factors, enhancers and genome organisation. A study now reveals a dynamic role for the transcription factor KLF4 in directing gene regulatory interactions during pluripotent cell reprogramming, demonstrating that transcription factors can function as chromatin organisers.

    • Peter J. Rugg-Gunn
    News & Views
    Nature Cell Biology
    Volume: 21, P: 1173-1174