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Advanced filters: Author: "Peter B. Dirks" Clear advanced filters

  • Two studies examine the cellular origins of peripheral nervous system tumors in mouse models of neurofibromatosis type 1 and conclude that stem cells may not be the culprits. Instead, more differentiated cells may give rise to and drive the tumors.

    • Peter B Dirks
    News & Views
    Nature Medicine
    Volume: 14, P: 373-375

  • The hypothesis that cancer is driven by tumour-initiating cells — popularly known as cancer stem cells — has recently attracted considerable attention, owing to the promise of a novel cellular target for the treatment of haematopoietic and solid malignancies. This Review considers recent advances in the cancer stem cell field, focusing on the challenges and opportunities for anticancer drug discovery.

    • Bin-Bing S. Zhou
    • Haiying Zhang
    • Peter B. Dirks
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 806-823