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Showing 1–8 of 8 results
Advanced filters: Author: "Petr Cejka" Clear advanced filters

  • DNA in the cytoplasm can be a sign of abnormalities such as viral infections or cancer. A protein with a role in DNA-damage response was unexpectedly found to activate defences against the threats indicated by cytoplasmic DNA.

    • Silvia Monticelli
    • Petr Cejka
    News & Views
    Nature
    Volume: 625, P: 457-458

  • The Mre11-Rad50 (MR) complex has key functions in the detection, signaling and repair of DNA breaks. Here the authors use transmission electron microscopy to show MR oligomerization is governed by a small beta-sheet protruding from the head domain of Rad50 at the base of the MR structure, and reveal MR head domain oligomerization is required for efficient DNA end resection.

    • Vera M. Kissling
    • Giordano Reginato
    • Matthias Peter
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated. Here the authors employ molecular modeling, biochemistry, and single molecule biophysics to reveal RPA directly promotes Dna2 recruitment, nuclease and helicase activities.

    • Ananya Acharya
    • Kristina Kasaciunaite
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection.

    • Elda Cannavo
    • Dominic Johnson
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Repair of broken DNA is vital for genome stability and to prevent the development of cancer. Research shows how the tumour-suppressor protein BRCA1 promotes a DNA-repair pathway called homologous recombination. See Article p.360

    • Petr Cejka
    News & Views
    Nature
    Volume: 550, P: 342-343

  • Ranhja et al. find that budding yeast Dna2 is modified by sumoylation, and that sumoylation reduces the nuclease, but not helicase activity of Dna2 in vitro. In cells, expression of a Dna2 version that cannot be sumoylated leads to impaired DNA end resection and cell division.

    • Lepakshi Ranjha
    • Maryna Levikova
    • Petr Cejka
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-12