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Showing 1–3 of 3 results
Advanced filters: Author: "Philip Barter" Clear advanced filters

  • A loss-of-function mutation in the gene encoding scavenger receptor class B member 1 (SRB1) has been identified. This mutation increases the risk of coronary heart disease (CHD) despite being associated with increased concentration of HDL cholesterol. Upregulation of SRB1 expression might be a novel therapeutic approach for reducing CHD risk.

    • Philip J. Barter
    • Kerry-Anne Rye
    News & Views
    Nature Reviews Cardiology
    Volume: 13, P: 249-250

  • High-density lipoproteins (HDLs) have various antiatherosclerotic effects; however, inflammation can cause HDL to become dysfunctional, which impairs its protective properties. In this Review, Rosenson and colleagues discuss the mechanisms by which HDL and apolipoprotein A-I protect against atherosclerosis, and how diagnostic and therapeutic approaches might target these proteins when they become dysfunctional.

    • Robert S. Rosenson
    • H. Bryan Brewer Jr
    • Nancy R. Webb
    Reviews
    Nature Reviews Cardiology
    Volume: 13, P: 48-60

  • High-density lipoprotein (HDL) is best known for its anti-atherosclerotic actions; however, emerging evidence suggests that it also has direct beneficial actions on plasma glucose control through multiple mechanisms. This Review discusses emerging evidence for the role of HDL-mediated glucose regulation in the pathophysiology of type 2 diabetes mellitus and the therapeutic potential for HDL elevation to prevent and manage the disease.

    • Brian G. Drew
    • Kerry-Anne Rye
    • Bronwyn A. Kingwell
    Reviews
    Nature Reviews Endocrinology
    Volume: 8, P: 237-245