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Showing 1–3 of 3 results
Advanced filters: Author: "Philipp Khaitovich" Clear advanced filters

  • The emergence of human cognition during evolution did not just involve mutations in brain-related genes. In this Review, Khaitovich and colleagues consider the contribution of human-specific changes in metabolism and gene expression, and their underlying mechanisms, to the human cognitive phenotype.

    • Mehmet Somel
    • Xiling Liu
    • Philipp Khaitovich
    Reviews
    Nature Reviews Neuroscience
    Volume: 14, P: 112-127

  • If most evolutionary changes affect the regulation rather than the structure of proteins, then studying the evolution of gene expression levels will help us to understand phenotypic changes. How can this approach identify the defining differences between humans and chimpanzees?

    • Philipp Khaitovich
    • Wolfgang Enard
    • Svante Pääbo
    Reviews
    Nature Reviews Genetics
    Volume: 7, P: 693-702

  • Long intergenic non-coding RNAs (lincRNAs) do not overlap protein-coding genes, although some lincRNA genes have minimal coding potential and can include small open reading frames that encode functional peptides. lincRNA functions include RNA stabilization and transcription regulation and the remodelling of chromatin and genome architecture. Recent insights suggest that lincRNAs broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity.

    • Julia D. Ransohoff
    • Yuning Wei
    • Paul A. Khavari
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 143-157