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Showing 1–2 of 2 results
Advanced filters: Author: "Pierre Savatier" Clear advanced filters

  • The Krüppel-like factors Klf4 and Klf5 have wide roles in cell biology including the regulation of pluripotency. In this study, Aksoy et al. demonstrate that Klf4 preferentially blocks the expression of endodermal markers in embryonic stem cells, whereas Klf5 negatively regulates mesodermal factors.

    • Irène Aksoy
    • Vincent Giudice
    • Pierre Savatier
    Research
    Nature Communications
    Volume: 5, P: 1-15

  • LIF/STAT3 signalling characterizes naive pluripotency in mouse embryonic stem cells (ESCs), but whether this pathway can sustain a similar state in human cells is not completely understood. Here the authors show that LIF stimulation and enhancement of STAT3 activity allow human ESCs to escape from FGF2 dependency and facilitates their entry into a naive-like state of pluripotency.

    • Hongwei Chen
    • Irène Aksoy
    • Pierre Savatier
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-17