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Showing 1–4 of 4 results
Advanced filters: Author: "Pierre-Louis Tharaux" Clear advanced filters

  • Rapidly progressive glomerulonephritis (RPGN) is a form of severe kidney injury that can lead to promptly lethal renal failure. Pierre-Louis Tharaux and colleagues report that HB-EGF is upregulated in RPGN, resulting in activation of EGFR in podocytes and their dysfunction. They further show that genetic loss of expression of HB-EGF or EGFR in a mouse model is protective, whereas pharmacological inhibition of EGFR, even after disease onset, is therapeutic. These results suggest a possible avenue of treatment for this potentially devastating condition.

    • Guillaume Bollée
    • Martin Flamant
    • Pierre-Louis Tharaux
    Research
    Nature Medicine
    Volume: 17, P: 1242-1250

  • In both focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN), kidney injury is characterised by the invasion of glomerular tufts by parietal epithelial cells (PECs). Here Lazareth et al. identify the tetraspanin CD9 as a key regulator of PEC migration, and find its upregulation in FSGS and CGN contributes to kidney injury in both diseases.

    • Hélène Lazareth
    • Carole Henique
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle.

    • Carole Henique
    • Guillaume Bollée
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • In this Review, the authors provide an overview of the roles of miRNAs in the development of chronic kidney disease, acute kidney injury and allograft injury. They also discuss the utilization of miRNAs as biomarkers and their potential as therapeutic targets in kidney disease.

    • Nassim Mahtal
    • Olivia Lenoir
    • Pierre-Louis Tharaux
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 643-662