The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice.
- Shang-Ze Li
- Qi-Peng Shu
- Xiao-Dong Zhang