The subunit composition of NMDA receptors (NMDARs) determines their biophysical, pharmacological and signalling properties. Paolettiet al.examine the contribution of individual receptor subtypes to normal physiology and disease, and the potential benefits of targeting specific NMDAR subtypes to counteract the deleterious effects of deregulated glutamatergic transmission.
- Pierre Paoletti
- Camilla Bellone
- Qiang Zhou