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Showing 1–3 of 3 results
Advanced filters: Author: "Qiao Yang" Clear advanced filters

  • LNK is a tumor suppressor in hematopoietic cancers, but its function in melanoma is unclear. Here, the authors show that the overexpression of LNK in melanomas correlate with hyperactive signaling of the RAS-RAF-MEK pathway and LNK enhances melanoma growth and survival and immune evasion by inhibiting IFN signalling.

    • Ling-Wen Ding
    • Qiao-Yang Sun
    • H. Phillip Koeffler
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Master regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression through activating its super-enhancer, and CCAT1 forms a complex with TP63 and SOX2, which regulates EGFR super-enhancers and enhances both the MEK/ERK1/2 and PI3K/AKT signaling pathways in SCC.

    • Yuan Jiang
    • Yan-Yi Jiang
    • H. Phillip Koeffler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13