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Showing 1–3 of 3 results
Advanced filters: Author: "Quentin M. Anstee" Clear advanced filters

  • NAFLD is a complex disease. Considerable variability exists in the severity and risk of morbidity and mortality among individuals with NAFLD, which could be influenced by genetic and environmental factors. Here, the authors discuss the latest knowledge on the genetics of NAFLD and how this genetic variation might determine disease phenotype and progression.

    • Quentin M. Anstee
    • Christopher P. Day
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 645-655

  • NAFLD, the hepatic manifestation of the metabolic syndrome, is a multifactorial condition — environmental factors influence an inherited genetic risk. Stender et al. now describe the additive effect of obesity and NAFLD-associated genetic polymorphisms on steatosis, elevated serum alanine aminotransferase levels and cirrhosis, remarkably illustrating the principle of gene–environment interactions.

    • Jake P. Mann
    • Quentin M. Anstee
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 14, P: 506-507

  • NAFLD is becoming much more common, and will soon be the major underlying aetiology for liver transplantation. This article discusses the evidence that NAFLD is a multisystem disease and outlines the factors that determine interindividual variation in the development and progression of NAFLD.

    • Quentin M. Anstee
    • Giovanni Targher
    • Christopher P. Day
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 330-344