RNF4 is an E3 ligase involved in ubiquitinating poly-SUMOylated proteins. The structure of the RNF4 dimer, along with modeling and functional analyses, now indicate that the dimer itself, rather than acting as a scaffold, plays a specific role in recognition by binding the E2~ubiquitin thioester and activating it for catalysis.
- Anna Plechanovová
- Ellis G Jaffray
- Ronald T Hay