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Showing 1–2 of 2 results
Advanced filters: Author: "R. Kiplin Guy" Clear advanced filters
  • Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.

    • James Inglese
    • Caroline E Shamu
    • R Kiplin Guy
    Comments & Opinion
    Nature Chemical Biology
    Volume: 3, P: 438-441
  • The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.

    • Anang A Shelat
    • R Kiplin Guy
    Comments & Opinion
    Nature Chemical Biology
    Volume: 3, P: 442-446