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Showing 1–6 of 6 results
Advanced filters: Author: "R. Nelson" Clear advanced filters

  • Cerebral blood flow regulation is essential for normal brain function. In this Review, Kisler and colleagues examine the cellular and molecular mechanisms that underlie cerebral blood flow regulation at the arteriole and capillary level, and how neurovascular dysfunction contributes to neurodegenerative disorders such as Alzheimer disease.

    • Kassandra Kisler
    • Amy R. Nelson
    • Berislav V. Zlokovic
    Reviews
    Nature Reviews Neuroscience
    Volume: 18, P: 419-434

  • In this Review, the authors highlight the potential for efficacy genetics to drive drug development and guide treatment options. They argue for the integration of routine pharmacogenetic screening into clinical development and propose strategies for identifying efficacy loci for marketed drugs.

    • Matthew R. Nelson
    • Toby Johnson
    • Dawn M. Waterworth
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 197-206

  • Matthew Nelson and colleagues investigate how well genetic evidence for disease susceptibility predicts drug mechanisms. They find a correlation between gene products that are successful drug targets and genetic loci associated with the disease treated by the drug and predict that selecting genetically supported targets could increase the success rate of drugs in clinical development.

    • Matthew R Nelson
    • Hannah Tipney
    • Philippe Sanseau
    Research
    Nature Genetics
    Volume: 47, P: 856-860