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Showing 1–2 of 2 results
Advanced filters: Author: "Raffaella Tonini" Clear advanced filters

  • BLINK2 is a light-activated potassium channel for optogenetic inhibition of neuronal activity. Alberio et al. apply the tool in systems as diverse as cultured rat neurons, mouse brain slices, behaving zebrafish and a rat model of neuropathic pain.

    • Laura Alberio
    • Andrea Locarno
    • Anna Moroni
    Research
    Nature Methods
    Volume: 15, P: 969-976

  • In a mouse model of cannabinoid tolerance, persistent activation of the eCB pathway impairs eCB-mediated long-term depression (LTD) preferentially at connections to striatopallidal neurons. This is associated with a shift in behavioral control from goal-directed action to habitual responding; both LTD and behavioral changes were rescued by modulating small-conductance Ca2+-activated K+ channels (SK channels).

    • Cristiano Nazzaro
    • Barbara Greco
    • Raffaella Tonini
    Research
    Nature Neuroscience
    Volume: 15, P: 284-293