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Showing 1–3 of 3 results
Advanced filters: Author: "Randal J. Kaufman" Clear advanced filters

  • The unfolded protein response (UPR) is an important pro-survival pathway that is often activated in tumour cells owing to endoplasmic reticulum stress that is caused by both intrinsic and extrinsic factors. Wang and Kaufman discuss the mechanisms of UPR activation in tumour cells, the importance of this pathway to cancer development and targeting strategies for therapeutic intervention.

    • Miao Wang
    • Randal J. Kaufman
    Reviews
    Nature Reviews Cancer
    Volume: 14, P: 581-597

  • The unfolded protein response pathway that is induced by endoplasmic reticulum (ER) stress has important roles in immune cell development and function, which have led to new insights into the pathogenesis of inflammatory diseases.

    • Joep Grootjans
    • Arthur Kaser
    • Richard S. Blumberg
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 469-484