The zebrafish, a well-established model organism in basic biomedical research, has also become tractable for numerous applications in drug discovery, from phenotypic screens to testing for toxicity. In this Review, MacRae and Peterson discuss how zebrafish have been used in such applications, advances that could make it an increasingly attractive tool — particularly for phenotypic screening — and the challenges that need to be addressed.
- Calum A. MacRae
- Randall T. Peterson
