Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: "Randy J Seeley" Clear advanced filters

  • A recent study has shown that a single dose of fibroblast growth factor (FGF) 1 into the central nervous system (CNS) of various mouse and rat models of type 2 diabetes results in profound and exceptionally long-lasting reductions in blood glucose. This work raises the possibility of truly revolutionary therapies for individuals with type 2 diabetes that target the brain FGF system.

    • Randy J Seeley
    • Darleen A Sandoval
    News & Views
    Nature Medicine
    Volume: 22, P: 709-711

  • One effect of weight-loss surgery is a change in food preferences. An analysis in rats shows that this is caused by altered nutrient signals in the intestine. These activate the vagus nerve to increase signalling in the brain by the neurotransmitter dopamine.

    • Darleen A. Sandoval
    • Randy J. Seeley
    News & Views
    Nature
    Volume: 542, P: 302-303

  • Many people smoke to keep their weight down. The identification of the molecular target in the brain for the appetite-suppressant effects of nicotine is a first step towards finding healthy alternatives to smoking for weight management.

    • Randy J. Seeley
    • Darleen A. Sandoval
    News & Views
    Nature
    Volume: 475, P: 176-177

  • The growing appreciation of the regulatory role of the central nervous system (CNS) in energy and glucose homeostasis has the potential to lead to more effective long–term treatments for obesity and type 2 diabetes. Here, Sandoval and colleagues discuss the CNS pathways involved, identify promising therapeutic targets and strategies for diabetes and consider the associated challenges hampering the development of new agents.

    • Darleen A. Sandoval
    • Silvana Obici
    • Randy J. Seeley
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 386-398

  • The authors of this Review integrate contributions of both central and peripheral glucagon-like peptide 1 (GLP-1), which is secreted from the intestine in response to nutrient ingestion, in a model of short-term and long-term control of energy balance. This model is discussed with respect to current GLP-1-based therapies and ongoing research that may help maximize the effectiveness of GLP-1-based treatment of obesity.

    • Jason G. Barrera
    • Darleen A. Sandoval
    • Randy J. Seeley
    Reviews
    Nature Reviews Endocrinology
    Volume: 7, P: 507-516

  • Sandoval and colleagues discuss emerging evidence for a role of the CNS in the regulation of glucose homeostasis and show that this regulation involves several neural circuits and mechanisms that also control energy balance. Disruption of these overlapping pathways may link the metabolic impairments that are associated with obesity and type 2 diabetes.

    • Bernadette E. Grayson
    • Randy J. Seeley
    • Darleen A. Sandoval
    Reviews
    Nature Reviews Neuroscience
    Volume: 14, P: 24-37