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Showing 1–4 of 4 results
Advanced filters: Author: "Raphael Kopan" Clear advanced filters

  • The cessation of nephrogenesis determines nephron endowments in mammals. Here the authors show that differential translation of Wnt antagonists versus agonists determines the tipping point from self-renewal to differentiation of nephron progenitors during nephrogenesis, using mutant mice with elevated nephron numbers.

    • Alison E. Jarmas
    • Eric W. Brunskill
    • Raphael Kopan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • It is unclear how Notch1 signals regulate both the maintenance of the endothelial fate and the endothelial-to-hematopoietic transition in the embryonic aorta. Here the authors show that those cells in which Notch1 ligand Jag1 is out-competed by Dll4 remain endothelial, while higher Jag1 activity leads to generation of hematopoietic stem cells.

    • Leonor Gama-Norton
    • Eva Ferrando
    • Anna Bigas
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Low nephron number is a risk factor for the development of hypertension, chronic kidney disease and kidney failure. This Review describes the mechanisms that modulate nephrogenesis and the timing of nephrogenesis cessation, focusing on environmental and intrinsic pathways that may be manipulated to enhance nephron endowment in susceptible individuals.

    • Alison J. Perl
    • Meredith P. Schuh
    • Raphael Kopan
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 683-695