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Showing 1–4 of 4 results
Advanced filters: Author: "Rebecca Page" Clear advanced filters

  • The Doc-Phd pair forms a bacterial toxin-antitoxin system, but the mechanism by which the Fic-family member Doc causes toxicity is not fully defined. New research shows that Doc unexpectedly functions as a kinase to phosphorylate elongation factor TU, thus inhibiting translation and leading to Doc-mediated growth arrest.

    • Wolfgang Peti
    • Rebecca Page
    News & Views
    Nature Chemical Biology
    Volume: 9, P: 756-757

  • Expanding the bacterial toxin-antitoxin system classes to a fifth class, GhoST was found to be involved in maintenance of persister cells, dormant cells that are tolerant of antibiotics. GhoS is the antitoxin, an endoribonuclease that cleaves the toxin mRNA ghoT, whose gene product is a membrane-lytic protein.

    • Xiaoxue Wang
    • Dana M Lord
    • Thomas K Wood
    Research
    Nature Chemical Biology
    Volume: 8, P: 855-861

  • NMR and ITC are used to define essential features of a p38α phosphatase interface that extend beyond the classic KIM binding site, and SAXS analysis software, incorporating NMR chemical shift data, are developed and applied to build a model of the p38α-HePTP complex.

    • Dana M Francis
    • Bartosz Różycki
    • Wolfgang Peti
    Research
    Nature Chemical Biology
    Volume: 7, P: 916-924

  • This Review article highlights bacterial toxin-antitoxin system components, their function and the mechanisms they use to affect diverse physiological functions and conditions, including dormancy and entry and exit from the persistent state defined by a high tolerance to antibiotics.

    • Rebecca Page
    • Wolfgang Peti
    Reviews
    Nature Chemical Biology
    Volume: 12, P: 208-214