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Showing 1–4 of 4 results
Advanced filters: Author: "Reuven Agami" Clear advanced filters

  • CRISPR–Cas9-based genome editing tools have been developed recently to study non-coding transcriptional regulatory elements, enabling the characterization of enhancers in their endogenous context. The applications, current limitations and future development of such CRISPR–Cas9 tools are discussed, with emphasis on identifying and characterizing enhancer elements in a high-throughput manner.

    • Rui Lopes
    • Gozde Korkmaz
    • Reuven Agami
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 597-604

  • Recent advances have allowed the genomic characterization of the extent and regulation of alternative polyadenylation. Here, the biological processes with which alternative polyadenylation has been associated, the mechanisms of its regulation and its involvement in disease are discussed.

    • Ran Elkon
    • Alejandro P. Ugalde
    • Reuven Agami
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 496-506

  • Gene expression is regulated by clusters of regulatory DNA sequences called enhancers. Basic design principles that protect enhancer networks against the harmful effects of genetic mutations have now been elucidated.

    • Ran Elkon
    • Reuven Agami
    News & Views
    Nature
    Volume: 609, P: 477-478

  • RNA-binding proteins include essential regulators of microRNA (miRNA) biogenesis, turnover and activity. RNA–RNA and protein–RNA interactions are essential for post-transcriptional regulation in normal development and could be deregulated in disease. This Review highlights the implications of these complex layers of regulation in cancer initiation and progression.

    • Marieke van Kouwenhove
    • Martijn Kedde
    • Reuven Agami
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 644-656