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Showing 1–2 of 2 results
Advanced filters: Author: "Richard M. Siegel" Clear advanced filters

  • Patients with autoinflammatory diseases develop pathological tissue inflammation in the absence of any autoreactive B or T cell responses. Recent studies have shown that defective regulation of pro-inflammatory immune components or protein handling pathways can provoke such autoinflammatory attacks. This Review describes the latest findings in the field and discusses their therapeutic significance.

    • Heiyoung Park
    • Ariel Bulua Bourla
    • Richard M. Siegel
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 570-580

  • Programmed cell death (PCD) is a vital process in the development and maintenance of immune cell populations. In this Review, the authors describe some of the major mechanisms of apoptosis, the role of defective PCD in autoimmunity, and the potential of therapeutic targeting of apoptosis pathways in patients with rheumatic diseases.

    • Madhu Ramaswamy
    • Min Deng
    • Richard M. Siegel
    Reviews
    Nature Reviews Rheumatology
    Volume: 7, P: 152-160