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Showing 1–2 of 2 results
Advanced filters: Author: "Richard Moreau" Clear advanced filters

  • The function of the innate immune system is suppressed in patients with acutely decompensated cirrhosis and predisposes these patients to bacterial infections. A new study shows that increased synthesis of the immunosuppressive prostaglandin PGE2 by circulating monocytes and resident macrophages and impaired hepatic synthesis of human serum albumin (HSA) are major contributors to immune suppression in cirrhosis (pages 518–523). The authors' data suggests a new avenue for therapy in acute decompensation of cirrhosis.

    • Vicente Arroyo
    • Richard Moreau
    News & Views
    Nature Medicine
    Volume: 20, P: 467-469

  • Microvesicles—extracellular vesicles released by virtually all cells—are now implicated in key processes of liver diseases including fibrosis and complications of cirrhosis and hepatocellular carcinoma. This Review describes studies assessing circulating microvesicle levels in patients with liver diseases, together with an insight into the mechanisms that could account for these changes. The potential of microvesicles as biomarkers in liver diseases is also discussed.

    • Sara Lemoinne
    • Dominique Thabut
    • Pierre-Emmanuel Rautou
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 350-361