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Showing 1–2 of 2 results
Advanced filters: Author: "Richard P. Lifton" Clear advanced filters

  • In mammalian neurons, cation–chloride cotransporters (CCCs) have vital roles in regulating the intracellular chloride concentration—which in turn determines the strength and polarity of γ-aminobutyric-acid-mediated neurotransmission—and in cell volume homeostasis. In this Review, Kahle et al. consider how breakdowns of chloride homeostasis resulting from alterations in CCC activity might contribute to various neurological disorders, including seizures and neuropathic pain, and they discuss the potential of CCCs as targets for novel therapeutic strategies.

    • Kristopher T Kahle
    • Kevin J Staley
    • David B Mount
    Reviews
    Nature Clinical Practice Neurology
    Volume: 4, P: 490-503

  • Next-generation sequencing approaches are becoming increasingly affordable for use in the clinical setting, and have the potential to provide valuable insights into the genetic underpinnings of complex neurological diseases. In this Review, Foo et al. discuss how whole-genome and whole-exome sequencing data can be deciphered, and consider how such data might be used for diagnosis and risk prediction in the neurology clinic.

    • Jia-Nee Foo
    • Jian-Jun Liu
    • Eng-King Tan
    Reviews
    Nature Reviews Neurology
    Volume: 8, P: 508-517