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Showing 1–2 of 2 results
Advanced filters: Author: "Rob Hooft van Huijsduijnen" Clear advanced filters
  • Despite considerable advances in malaria medicines in the past 20 years, the global burden of malaria remains substantial. Moreover, continued emergence of drug resistance ensures that new antimalarials will be needed in the near future. Wells and colleagues summarize the current landscape of antimalarial therapies and investigational drugs, highlighting the progress made, identifying gaps in terms of target profiles and recommending priorities for future research.

    • Timothy N. C. Wells
    • Rob Hooft van Huijsduijnen
    • Wesley C. Van Voorhis
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 424-442
  • The quality of the chemical starting points for small-molecule drug discovery is a key factor in improving the likelihood of clinical success. In this article, experts from several organizations involved in drug discovery for malaria, tuberculosis and neglected tropical diseases present disease-specific criteria for hits and leads, and discuss the underlying rationale.

    • Kei Katsuno
    • Jeremy N. Burrows
    • B. T. Slingsby
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 751-758