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Showing 1–10 of 10 results
Advanced filters: Author: "Robert Edwards" Clear advanced filters

  • The Na+/H+ exchanger NHE9 is proposed to regulate the H+ electrochemical gradient across endosomal membranes. Here, the authors find that NHE9 knockout mice show autism spectrum disorder-like behaviors and disrupted synaptic vesicle exocytosis due to impaired presynaptic calcium entry.

    • Julie C. Ullman
    • Jing Yang
    • Robert H. Edwards
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • The authors used knockout mice to demonstrate the normal function of the protein α-synuclein, which has a central role in Parkinson's and other neurodegenerative diseases. The presynaptic protein promoted dilation of the exocytotic fusion pore, and mutations that cause Parkinson's disease specifically impaired this normal function.

    • Todd Logan
    • Jacob Bendor
    • Robert H Edwards
    Research
    Nature Neuroscience
    Volume: 20, P: 681-689

  • The authors report that rat brain glutamatergic synaptic vesicles express monovalent cation/H+ exchangers that convert the Δψ of the proton electrochemical gradient into Δψ. They find that this K+/H+ exchange stimulates the accumulation of glutamate into vesicles, regulating glutamate release and thus synaptic transmission.

    • Germaine Y Goh
    • Hai Huang
    • Robert H Edwards
    Research
    Nature Neuroscience
    Volume: 14, P: 1285-1292

  • Mounting evidence indicates that cognitive and emotional processes are important determinates of how individuals with rheumatic disorders experience pain. Depression and catastrophizing, in particular, shape pain responses and pain outcomes through several distinct pathways, and could represent targets for improving and individualizing therapy.

    • Robert R. Edwards
    • Christine Cahalan
    • Jennifer A. Haythornthwaite
    Reviews
    Nature Reviews Rheumatology
    Volume: 7, P: 216-224

  • Despite the contribution of mechanical pain to the morbidity associated with inflammation and trauma, the primary sensory neurons that convey this sensation have not been identified. Using knockout mice, the loss of the low abundance vesicular glutamate transporter VGLUT3, expressed by a small subset of peripheral sensory neurons projecting to areas implicated in persistent pain caused by injury, is now shown to specifically impair mechanical pain sensation.

    • Rebecca P. Seal
    • Xidao Wang
    • Robert H. Edwards
    Research
    Nature
    Volume: 462, P: 651-655

  • Glutamate transporters influence the kinetics of synaptic transmission by acutely buffering synaptically released glutamate. In addition to high synaptic density of EAAT2, the transporter's high mobility contributes to function.

    • Robert H Edwards
    News & Views
    Nature Neuroscience
    Volume: 18, P: 166-168

  • In early germline development, extra-embryonic signals trigger a regulatory network that induces the specification and subsequent epigenetic reprogramming of primordial germ cells, the precursors of sperm and eggs. Here, the authors review germline specification and reprogramming in humans, and discuss the crucial mechanistic differences between these processes in humans and mice.

    • Walfred W. C. Tang
    • Toshihiro Kobayashi
    • M. Azim Surani
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 585-600