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Showing 1–4 of 4 results
Advanced filters: Author: "Robert J. Klose" Clear advanced filters

  • Recent findings have demonstrated that Polycomb repressive complexes (PRCs) control gene expression through their co-recruitment to specific CpG island elements with transcription factors and non-coding RNAs. Moreover, they revealed that the interplay between PRC1 and PRC2 to achieve transcriptional repression is more intricate than was previously thought.

    • Neil P. Blackledge
    • Nathan R. Rose
    • Robert J. Klose
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 643-649

  • Chromatin modifications affect many aspects of epigenetic inheritance and cell biology. The authors focus on evolutionary relationships among proteins containing the Jumonji C domain — the largest class of histone demethylases — and discuss their functions in relation to potential enzymatic activities.

    • Robert J. Klose
    • Eric M. Kallin
    • Yi Zhang
    Research
    Nature Reviews Genetics
    Volume: 7, P: 715-727

  • Post-translational modification of histones can profoundly affect chromatin structure and function. The discovery that histone H3 Arg2 methylation is a widespread silencing modification that inhibits histone H3 Lys4 trimethylation extends our understanding of how active and silenced chromatin states are maintained.

    • Robert J Klose
    • Yi Zhang
    News & Views
    Nature Structural & Molecular Biology
    Volume: 14, P: 1058-1060

  • Methylation of histone residues is important for the regulation of gene transcription, epigenetic inheritance and cell fate. Histone methylation was long considered a stable modification, but the recent identification of a histone deiminase and histone demethylases has shown that histone methylation can be dynamically regulated.

    • Robert J. Klose
    • Yi Zhang
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 307-318