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Showing 1–10 of 10 results
Advanced filters: Author: "Robert J. Lefkowitz" Clear advanced filters

  • In this Review, the authors discuss recent advances in the characterization of β-arrestin-mediated signalling and biased agonism at seven-transmembrane receptors, and address the implications of these for drug discovery involving this ubiquitous superfamily of receptors.

    • Sudarshan Rajagopal
    • Keshava Rajagopal
    • Robert J. Lefkowitz
    Reviews
    Nature Reviews Drug Discovery
    Volume: 9, P: 373-386

  • Pharmacologist who won a Nobel prize for his discovery of G proteins.

    • Robert J. Lefkowitz
    Comments & Opinion
    Nature
    Volume: 529, P: 284

  • The crystal structure of a second G protein–coupled receptor sheds light on these key pharmaceutical targets.

    • Robert J Lefkowitz
    • Jin-Peng Sun
    • Arun K Shukla
    News & Views
    Nature Biotechnology
    Volume: 26, P: 189-191

  • A given G protein-coupled receptor can signal through a range of downstream transducers depending on the stimulating ligand, enabling biased signalling towards different biological outcomes. Lefkowitz and colleagues describe the latest advances in the field, including efforts to harness biased signalling for improved therapeutic outcomes.

    • Jeffrey S. Smith
    • Robert J. Lefkowitz
    • Sudarshan Rajagopal
    Reviews
    Nature Reviews Drug Discovery
    Volume: 17, P: 243-260

    • Kristen L. Pierce
    • Richard T. Premont
    • Robert J. Lefkowitz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 3, P: 639-650

  • The melanocortin system is a central element in the control of energy homeostasis, sexual behaviour and autonomic functions. Here, Wikberg and Mutulis discuss the potential of targeting melanocortin receptors across multiple therapeutic areas, and highlight opportunities and challenges for drug discovery in the melanocortin pathway.

    • Jarl E. S. Wikberg
    • Felikss Mutulis
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 307-323

  • The recent growth in the number of academic drug discovery centres is providing new opportunities to couple the curiosity-driven research culture in academia with rigorous preclinical drug discovery practices used in industry. To realize the potential of these opportunities, it is important that academic researchers understand the risks in several key areas — including organization, target selection, assay design, medicinal chemistry and preclinical pharmacology — which are discussed in this article.

    • Jayme L. Dahlin
    • James Inglese
    • Michael A. Walters
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 279-294

  • Sphingolipids are a major class of lipids, comprising various species with diverse functions. In addition to being structural elements of membranes, many sphingolipids are bioactive and regulate a myriad of cellular processes. Recent advances have shed new light on the complexity of sphingolipid metabolism and their various roles in physiology and disease.

    • Yusuf A. Hannun
    • Lina M. Obeid
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 175-191

  • The sphingolipids constitute an important class of bioactive lipids that includes ceramide and sphingosine-1-phosphate (S1P). Deciphering the cellular functions of sphingolipids requires an understanding of the complex metabolic pathways and the mechanisms that regulate lipid generation and lipid action.

    • Yusuf A. Hannun
    • Lina M. Obeid
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 139-150