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Showing 1–17 of 17 results
Advanced filters: Author: "Robert Langer" Clear advanced filters

  • Wanted: biomaterials for a risky journey. Giovanni Traverso and Robert Langer explain the gastrointestinal frontier.

    • Giovanni Traverso
    • Robert Langer
    Comments & Opinion
    Nature
    Volume: 519, P: S19

  • Metastasis accounts for the vast majority of cancer deaths. The potential of using nanoparticles to diagnose and to treat metastatic cancer is highlighted in this Review.

    • Avi Schroeder
    • Daniel A. Heller
    • Daniel G. Anderson
    Reviews
    Nature Reviews Cancer
    Volume: 12, P: 39-50

  • The goal of management for both type 1 and type 2 diabetes is the maintenance of blood glucose levels within healthy normoglycaemic ranges. However, safely achieving this goal using current therapeutic approaches has proved challenging. Here, Langer and colleagues review the developing role of nanotechnology in diabetes management, from diagnosis and disease monitoring to therapeutics.

    • Omid Veiseh
    • Benjamin C. Tang
    • Robert Langer
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 45-57

  • This Review introduces the biological barriers to gene deliveryin vivoand discusses recent advances in material sciences, nanotechnology and nucleic acid chemistry that have yielded promising non-viral systems for the delivery of DNA, mRNA, small interfering RNAs and microRNAs, some of which are currently undergoing testing in clinical trials.

    • Hao Yin
    • Rosemary L. Kanasty
    • Daniel G. Anderson
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 541-555

  • Sticking plasters revolutionized the protection of minor wounds, but they're not ideal for fragile skin. A material that mimics the adhesive properties of certain beetles' feet might provide a solution.

    • Jeffrey M. Karp
    • Robert Langer
    News & Views
    Nature
    Volume: 477, P: 42-43

  • A microneedle-containing patch that is designed to sense elevated blood glucose levels and to respond by releasing insulin could offer people with diabetes a less-painful and more-reliable way to manage their condition.

    • Omid Veiseh
    • Robert Langer
    News & Views
    Nature
    Volume: 524, P: 39-40

  • Many materials-based therapeutic systems have reached the clinic or are in clinical trials. Here we describe materials design principles and the construction of delivery vehicles, as well as their adaptation and evaluation for human use.

    • Jeffrey A. Hubbell
    • Robert Langer
    Comments & Opinion
    Nature Materials
    Volume: 12, P: 963-966

  • The development of generic therapeutic nanoparticles faces a combination of scientific, patent and regulatory challenges.

    • Paul Burgess
    • Peter Barton Hutt
    • Stephen Zale
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 1267-1270

  • This Review by Mitchellet al. summarizes how engineering and the physical sciences have advanced oncology by highlighting four important areas: the physical microenvironment of the tumour, drug delivery, cellular and molecular imaging, and microfluidics and microfabrication.

    • Michael J. Mitchell
    • Rakesh K. Jain
    • Robert Langer
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 659-675

  • Biological drugs offer high specificity and potency, but their formulation and delivery pose substantial challenges. Here, the authors highlight recent advances in formulation strategies, describe current and emerging delivery routes and review the potential of targeted and intracellular delivery of biologics.

    • Samir Mitragotri
    • Paul A. Burke
    • Robert Langer
    Reviews
    Nature Reviews Drug Discovery
    Volume: 13, P: 655-672

  • RNA interference holds vast potential as a therapeutic strategy for both disease prevention and treatment, but its use has so far been hampered by a lack of safe and effective delivery techniques. In their Review, Anderson and colleagues discuss the challenges associated with small interfering RNA delivery and highlight promising novel synthetic delivery agents.

    • Kathryn A. Whitehead
    • Robert Langer
    • Daniel G. Anderson
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 129-138

  • Genome editing has emerged as an attractive approach to therapeutically manipulate gene expression. Here, Anderson and colleagues provide an overview of genome-editing platforms, focusing on the methods and challenges of intracellular biomacromolecule delivery. Preclinical and clinical trials involving genome-editing technologies are also discussed.

    • Hao Yin
    • Kevin J. Kauffman
    • Daniel G. Anderson
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 387-399

  • Although prolactin's action on the mammary gland is well known, it is also found in the circulation of males and its receptor (PRLR) is expressed in the prostate. Furthermore, studies have supported the contribution of the canonical PRLR-Jak2-Stat5a/b pathway to prostate cancer tumorigenesis and progression. In this Review, the authors discuss the data regarding the role of prolactin in the prostate and consider the therapeutic potential of targeting prolactin signaling pathways in the treatment of advanced prostate cancer.

    • Vincent Goffin
    • David T. Hoang
    • Marja T. Nevalainen
    Reviews
    Nature Reviews Urology
    Volume: 8, P: 597-607